¥í¥°¥¤¥ó¤·¤Æ¤µ¤é¤Ëmixi¤ò³Ú¤·¤â¤¦

¥³¥á¥ó¥È¤òÅê¹Æ¤·¤Æ¾ðÊó¸ò´¹¡ª
¹¹¿·ÄÌÃΤò¼õ¤±¼è¤Ã¤Æ¡¢ºÇ¿·¾ðÊó¤ò¥²¥Ã¥È¡ª

ÌôºÞ»Õ¥³¥ß¥å¤Î¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹¤ÈÌô

  • mixi¥Á¥§¥Ã¥¯
  • ¤³¤Î¥¨¥ó¥È¥ê¡¼¤ò¤Ï¤Æ¤Ê¥Ö¥Ã¥¯¥Þ¡¼¥¯¤ËÄɲÃ
¿·¿ÍÌôºÞ»Õ¤Ç¤¹¡£¶µ¤¨¤Æ¤¯¤À¤µ¤¤ÀèÇÚÊým(_ _)m
¤è¤¯¡¢¥°¥ì¡¼¥×¥Õ¥ë¡¼¥ÄÅù¤Î²Ìʪ¤Î¥¸¥å¡¼¥¹Åù¤ÇÌô¤ÎºîÍѤ¬Áý¶¯¤µ¤ì¤¿¤ê¸º¼å¤µ¤ì¤¿¤ê¤¹¤ë¤È»×¤¦¤Î¤Ç¤¹¤¬¡¢²¿»þ´Ö¤«¤ª¤¤¤ÆÉþÍѤ¹¤ì¤ÐÂç¾æÉפʤâ¤Î¤Ê¤Î¤Ç¤·¤ç¤¦¤«¡©¤½¤ì¤È¤âÀ¸³è¤«¤éÀä¤Ä¤Ù¤­¤Ç¤·¤ç¤¦¤«¡©

¥³¥á¥ó¥È(19)

¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹¤Ï¾®Ä²¤Ç¤ÎCYP3A4¤òÍÞÀ©¤·¡¢ÌôʪÂå¼Õ¤òÁ˳²¤·¤Þ¤¹¡£
¤½¤Î·ë²ÌÌôʪ¤Î·ìÃæÇ»ÅÙ¤¬¾å¤¬¤ê¡¢ºîÍѤ¬¶¯¤Þ¤ê¤Þ¤¹¤è¤Í¡£

¤½¤ÎCYPÍÞÀ©ºîÍѤÏ3¡Á4Æü³¤¯¤½¤¦¤Ç¤¹¤Î¤Ç¡¢ÉþÍÑ»þ´Ö¤ò¥º¥é¤»¤Ð¤è¤¤¤È¤¤¤¦ÌäÂê¤Ç¤Ï¤Ê¤¤¤ß¤¿¤¤¤Ç¤¹¡£

¤Á¤Ê¤ß¤Ë¡¢¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¼«ÂÎ¤âÆ±¤¸¤è¤¦¤Ë¹Í¤¨¤¿Êý¤¬¤¤¤¤¤½¤¦¤Ç¤¹¡£

¤µ¤é¤Ë¾Ü¤·¤¤Êý¤¤¤é¤Ã¤·¤ã¤¤¤Þ¤·¤¿¤é¡¢Êä­¤ª´ê¤¤¤·¤Þ¤¹¡£
¾®Ä²¤ÎCYP3A4ÍÞÀ©ºîÍѡĤ³¤ì¡¢À¨¤¯Á°¤«¤é¸¦µæ¤µ¤ì¤Æ¤Þ¤¹¤è¤Í¡£

¤è¤¦¤ä¤¯»Ô̱¸¢¤òÆÀ¤¿¤Î¤Ç¤·¤ç¤¦¤«¤Í¡Ä¡£

¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤ä¥ª¥ì¥ó¥¸¤Ë´Þ¤Þ¤ì¤ë¡¢¥¯¥Þ¥ê¥ó¡Ê¤À¤Ã¤¿¤«¤Êexclamation & question¡ËͶƳÂΤ¬¡¢¡Ö°­¤µ¡×¤ò¤¹¤ë¤è¤¦¤Ëµ­²±¤·¤Æ¤¤¤Þ¤¹¤¬¡Ä¡£
¡ÊÌô³Ø²ñ¤Î¶å½£»ÙÉô²ñ¤Ç¡¢½é¤á¤ÆÊÙ¶¯¤·¤Þ¤·¤¿¤¬¡Ä¡Ë

¤³¤ì¤òÊÙ¶¯¤·¤¿¤Î¤¬£¹Ç¯ÄøÁ°¤Ç¤¹¤·¡¢Ìȵö¤ò¼èÆÀ¤·¤Æ¤«¤é¡ÖÄ´ºÞ¤Ë½¾»ö¤·¤Æ¤¤¤Ê¤¤ÌôºÞ»Õ¡×¤Ê¤Î¤Ç¡¢¥¨¥¢¡¦¥Ý¥±¥Ã¥ÈÂ礭¤¹¤®¤Ç¤¹¤¬¡Ä¤¢¤»¤¢¤»¡£

Åö»þ¤«¤éºîÍÑ»ý³À­¤¬ëð¤ï¤ì¤Æ¤¤¤¿¤Î¤Ç¡¢¡Ö¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹¤ä¥ª¥ì¥ó¥¸¥¸¥å¡¼¥¹¤È°ì½ï¤ËÉþÍѤ¹¤ë¤³¤È¤ÏÈò¤±¤Æ²¼¤µ¤¤¤Í¡×¤È¤¤¤¦ÉþÌô»ØÆ³¤¬¡¢¤ä¤Ã¤Ñ¤êŬÅö¤«¤â¤·¤ì¤Þ¤»¤ó¤Í¡£
ÆÈΩ¹ÔÀ¯Ë¡¿Í ¹ñΩ·ò¹¯Ž¥±ÉÍܸ¦µæ½ê¤Î¡Ö·ò¹¯¿©ÉʤΰÂÁ´À­¡¦Í­¸úÀ­¾ðÊó¡×¥µ¥¤¥È¤Ë¾Ü¤·¤¯Å»¤á¤Æ¤¢¤ê¤Þ¤¹¤è¡£

¢­¾åµ­¥µ¥¤¥ÈÆâ¡¦¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä´ØÏ¢¥Ú¡¼¥¸
http://hfnet.nih.go.jp/contents/detail825.html

»²¹Íʸ¸¥¤¬¥ê¥ó¥¯¤µ¤ì¤Æ¤ë¤Î¤Ç¡¢¾ÜºÙ¤òÃΤë¤Î¤Ë¤âÊØÍø¤Ç¤¹¡£¡Ê¥ê¥ó¥¯Àè¤Ï±Ñʸ¤Ç¤¹¤±¤É¤Í¡Ë
¥ª¥ì¥ó¥¸¤ÏÂç¾æÉפǤ¹¡£
¤Ê¤¼¤«¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤À¤±¡Ä
¥Ê¥ê¥ó¥¸¥ó¤Ê¤É¤¬¡¢CYP¤À¤±¤Ç¤Ê¤¯PÅüÃÁÇò¤âÁ˳²¤·¤Þ¤¹¡£
mizu¡ú¤µ¤ó¤¬½ñ¤«¤ì¤Æ¤¤¤ë¤è¤¦¤Ë£³¡Á£´ÆüÁ˳²ºîÍѤ¬Â³¤­¤Þ¤¹¡£
²ÌÆù¤ò¿©¤Ù¤Æ¤âƱÍͤǤ¹¡£

http://www.jstage.jst.go.jp/article/yakushi/122/5/323/_pdf/-char/ja/

¤¦¤Á¤Î´µ¼Ô¤µ¤ó¤Ë
¡Ö¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤¬¥À¥¤¥¨¥Ã¥È¤Ë¤¤¤¤¤Ã¤ÆË¿M¤µ¤ó¤¬¤ä¤Ã¤Æ¤¤¤ë¤ªÃë¤ÎÈÖÁȤǸÀ¤Ã¤Æ¤¿¤±¤É¡¢ÀäÂФȤäÁ¤ã¤À¤á¤Ê¤Î¡©¡×
¤È¤¤¤¦Êý¤¬¤¤¤Þ¤·¤¿¡£
Áê¸ßºîÍѤÎÄøÅ٤Ͽͤˤè¤Ã¤ÆÂå¼Õ¹ÚÁǤÎÎ̤â°ã¤¦¤Î¤Ç¡¢°ì³µ¤Ë¤Ï¸À¤¨¤Þ¤»¤ó¤¬¡¢»ä¤ÏÀݤé¤Ê¤¤ÍÍ¤Ë»ØÆ³¤·¤Æ¤¤¤Þ¤¹¡£
¤Þ¤À¤Þ¤À̤½Ï¼Ô¤Î³ØÀ¸¤Ç¤¹¤¬¡¢»ä¤Îʹ¤¤¤¿¤³¤È¤Î¤¢¤ëÏᦡ¦
¥«¥ë¥·¥¦¥àÙɹ³Ìô¤Î¤Ê¤«¤Ç¤â¡¢CYPÁ˳²¤ò¼õ¤±¤ä¤¹¤¤¤â¤Î¼õ¤±¤Ë¤¯¤¤¤â¤Î¤¬¤¢¤ë¤é¤·¤¤¤Ç¤¹¡£
¤¢¤È¡¢¥Ô¥ó¥¯¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤ÏCYPÁ˳²¤¬¤Ê¤¤Ëô¤Ï¾¯¤Ê¤¤¤é¤·¤¤¡£
¤Þ¤¿¡¢²ÌÆù¤ÈÈé¤Î´Ö¤Ë¸¶°øÊª¼Á¡Ê¥¯¥Þ¥ê¥óͶƳÂΡˤ¬Â¿¤¤¤é¤·¤¤¤Ç¤¹¡£
¤À¤«¤é¡¢È餴¤È¤Ä¤Ö¤·¤Æºî¤ë¥¸¥å¡¼¥¹¤ËÃí°Õ¤¬É¬Íפǡ¢²ÌÆù¤ò¿©¤Ù¤ë¤³¤È¤Ï¤µ¤Û¤Éµ¤¤Ë¤·¤Ê¤¯¤Æ¤¤¤¤¤é¤·¤¤¡£

´Ö°ã¤Ã¤Æ¤¤¤ë¤³¤È¤¬¤¢¤Ã¤¿¤é¤¹¤ß¤Þ¤»¤ó¡£
¤Á¤Ê¤ß¤Ë¡¢Â裹£²²ó¤Î¹ñ»î¤ËGFJ¤ÎCYPÁ˳²½Ð¤Æ¤Þ¤·¤¿¤è¡£
¡Ö·ò¹¯¿©ÉʤΰÂÁ´À­¡¦Í­¸úÀ­¾ðÊó¡×¤Ë¤«¤Ê¤ê¾Ü¤·¤¯µ­ºÜ¤µ¤ì¤Æ¤¤¤Þ¤¹¤«¤é¢¬¤Ë¥ê¥ó¥¯¤¬¤µ¤ì¤Æ¤¤¤ë¤è¤¦¤Ê¤Î¤Ç¡¢»²¹Í¤Ë¤Ê¤ê¤Þ¤¹¤Í¡£
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Ï½éÀ¸´»µÌ°¡Â°¤Î¥Ö¥ó¥¿¥ó¡Ê¥¶¥Ü¥ó¶è¡Ë¤Ë°¤·¤Æ¤ª¤ê¡¢¤³¤ì¤Ë¤Ï¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Î¾¤ËȬºó¡¢ÈÕÇòÍ®¡¢¥Ö¥ó¥¿¥ó¡¢¥¹¥£¡¼¥Æ¥£¤Ê¤É¤âÆþ¤ë¤è¤¦¤Ç¤¹¤«¤éƱÍͤÎÃí°Õ¤¬É¬ÍפǤ¹¡£
·ò¾ï¼Ô¤Ë¤è¤ë¥Õ¥§¥í¥¸¥Ô¥ó½ùÊüºÞ¤ËÂФ¹¤ë¡¢¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¡¢²Ì¼Â¡¢²ÌÈ饨¥­¥¹¤Î±Æ¶Á¤òÈæ³Ó¤·¤¿»î¸³¤Ç¤Ï¡¢¤¤¤º¤ì¤â¿å¤ËÈæ¤Ù¤Æ¥Ð¥¤¥ª¥¢¥Ù¥¤¥é¥Ó¥ê¥Æ¥£¤¬Áý²Ã¤·¤¿Êó¹ð¤â¤¢¤ê¤Þ¤¹¡£¥¸¥å¡¼¥¹¤À¤±¤Ç¤Ï¤Ê¤¯¡¢²Ì¼Â¤ä¥Þ¡¼¥Þ¥ì¡¼¥É¤Î¤è¤¦¤Ê²ÌÈ餬Æþ¤Ã¤¿¿©ÉʤǤâÁê¸ßºîÍѤòµ¯¤³¤¹²ÄǽÀ­¤Ï¤¢¤ë¤È¤¤¤¦¤³¤È¤Ç¤¹¡£
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Ï¼Â¤ÏÂç¾æÉפÀ¤Ã¤¿¤Ç¤¹¤è¤Í¡ª
¤¿¤·¤«Èé¤Ë¿¤¤¤ó¤Ç¤¹¤è¤Í¡Á

¼«Ê¬¤Ï¼Â¤è¤ê¤â¥¸¥å¡¼¥¹¡ÊÈé¤Þ¤Ç¹Ê¤Ã¤Æ¤ë¡Ë¤òµ¤¤ò¤Ä¤±¤Æ¤¯¤À¤µ¤¤¤ÈÅÁ¤¨¤Æ¤Þ¤¹¡ª¥¸¥å¡¼¥¹¤ËÈæ¤Ù¤Æ¼Â¤Î¤Û¤¦¤â¤É¤ÎÄøÅٱƶÁ¤¹¤ë¤ó¤Ç¤¹¤«¤Í¡©¿ôÃͤʤɤ狼¤ëÊý¤¤¤¿¤é¤è¤í¤·¤¯¤Ç¤¹¡¦¡¦¡¦¡ª
Ìô¨­ºÞ¨­»Õ¨­¤µ¨­¤ó¨­¡ª¨­´è¨­Ä¥¨­¤í¨­¤¦¨­¡ª¨­Ą̈­¿®¨­
¤ËÌÌÇò¤¤¡¢»²¹Í¤Ë¤Ê¤ëÇÛ¿®¤¬¤¢¤ê¤Þ¤·¤¿

¡Ö¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¡×¡Ö¥¶¥Ü¥ó¡×°Ê³°¤âÍ×Ãí°Õ¡ª
¥Ï¥Ã¥µ¥¯¤È¥¿¥¯¥í¥ê¥à¥¹¤ÎÁê¸ßºîÍÑ
http://iphiss.jp/
¥¸¥å¡¼¥¹¡¢²ÌÆù¤Ïɸ½à²½¤·¤Å¤é¤½¤¦¤Ê¤Î¤Ç¡¢¤³¤ì¤é¤òÈæ¤Ù¤¿¿ô»ú¤ò½Ð¤¹¤Î¤ÏÆñ¤·¤½¤¦¤Ç¤¹¤Í¡£
£³¡¢£´Ç¯Á°¤ÎÆü·Ð£Ä£É¤Ë¾Ü¤·¤¯½Ð¤Æ¤¿¤è¤¦¤Ê¡¦¡¦¡¦¡£
3´¬¤¢¤¿¤ê¤Ç¤¹¤Í¡£
³Î¤«¥ª¥ì¥ó¥¸¿§¤Î¥ä¥Ä¤Ç¤¹¤Í¡¼¡£
²¿²ó¤â°ú¤ÃÄ¥¤ê½Ð¤·¤ÆÆÉ¤ß¤Þ¤·¤¿¡£

ÌÀÆü¸«¤Æ¤ß¤Þ¤¹¡£

¤¦¤Á¤ÎÌô¶É¤ËÍè¤Æ¤¤¤ë´µ¼Ô¤µ¤ó¤Ç¡¢
¼ÂºÝ¤Ë¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹¤ÈCaÙɹ³ºÞ¤Ç
¤Ò¤É¤¤Æ°Ø©¤ä¤Õ¤é¤Ä¤­¤Ê¤ÉÉûºîÍÑȯ¸½¤·¤Æ¤¤¤¿Êý¤¬¤¤¤Þ¤·¤¿¤è¡ª¡ª

°ÊÁ°¤«¤é¤º¤Ã¤È¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹¤ò°û¤ó¤Ç¤¤¤¿¤½¤¦¤Ç¡¢
¹ß°µºÞ¤¬¦Â¥Ö¥í¥Ã¥«¡¼¤«¤éCaÙɹ³ºÞ¤ËÊѤï¤Ã¤¿¤È¤­¤Ë
Áê¸ßºîÍѤˤè¤ëÉûºîÍѤòȯ¸½¤·¤Æ¤·¤Þ¤Ã¤¿¤è¤¦¤Ç¤¹¡£

¸åÆü¡Ê¿ôǯ¸å¡Ë¤Ëʹ¤¤¤¿ÏäÀ¤Ã¤¿¤Î¤Ç¡¢
Åö»þ¤Ï²¿¤â¥±¥¢¤ò¤Ç¤­¤Æ¤¤¤Þ¤»¤ó¤Ç¤·¤¿¤¬¡¦¡¦¡¦¤¢¤»¤¢¤»¡ÊÈô¤Ó»¶¤ë´À¡Ë

°ÊÍè¡¢CaÙɹ³ºÞ¿·µ¬¤Ç½èÊý¤µ¤ì¤ëÊý¤Ë¤Ï¡¢
ÀѶËŪ¤Ë¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¥¸¥å¡¼¥¹³Îǧ¤·¤Æ¤Þ¤¹¤Ò¤è¤³
»ä¤â³ØÀ¸¤Ç¤¹¤Î¤Ç¡¢¾¯¤Ê¤¤Ãμ±¤Ç¤¹¤¬¡¢¥°¥ì¥Õ¥ëÃæ¤Î¥Ù¥ë¥¬¥â¥Ã¥Á¥ó¤Ë£Ð£´£µ£°Á˳²ºîÍѤ¬¤¢¤ë¡Ä¤È¤­¤¤¤¿¤³¤È¤¬¤¢¤ê¤Þ¤¹¡£

¤Þ¤¿¡¢Ã±½ã¤Ë¹Í¤¨¤Æ¡¢
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤½¤Î¤â¤Î¤À¤Ã¤¿¤é¿¤¯¤Æ£±¥³¤·¤«¿©¤Ù¤é¤ì¤Ê¤¤¤±¤É¡¢
¥¸¥å¡¼¥¹¡ÊÀ¸¹Ê¤ê¡Ëºî¤í¤¦¤È»×¤Ã¤¿¤é¡¢¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä£µ¡¢£¶¤³É¬ÍפˤʤäƤ¯¤ë¡Ä
¤Ã¤Æ¤æ¤¦¡¢Î̤ÎÌäÂê¤â¤¢¤ë¤«¤â¤Ã¤Æ»×¤¤¤Þ¤¹¡ª
²¿¤«º¬ËÜŪ¤ÊÌäÂ꤬¡¦¡¦¡¦

Áê¸ßºîÍѤˤè¤ëÉûºîÍÑ¤Î´í¸±À­¤¬¤¢¤ë¤Î¤Ç
Àݤé¤Ê¤¤¤è¤¦¤Ë»ØÆ³¤¹¤ë¤Î¤Ç¤Ï̵¤¤¤Ç¤¹¤«¡©

²ÌÆù¤Ç±Æ¶Á¤¬¤¢¤Ã¤¿Êó¹ð¤¬¤¢¤ê¡¢Ä¹´ü´ü´Ö¤Ë
±Æ¶Á¤¬µÚ¤ÖÊó¹ð¤¬¤¢¤ë°Ê¾åÀݤé¤Ê¤¤¤è¤¦¤Ë
»ØÆ³¤¹¤ë¤Ù¤­¤Ç¤¹¡£

¥Ô¥ó¥¯¤Ê¤é¡¦¡¦²ÌÆù¤Ê¤é¡¦¡¦¸¶°ø¤È¹Í¤¨¤é¤ì¤ë
ʪ¼Á¤¬¾¯¤Ê¤¤¤Î¤ÇOK¤È¸À¤¦ÌäÂê¤Ç¤Ï¤¢¤ê¤Þ¤»¤ó¡£
»ä¤â¶½Ì£¤Ç¥Õ¥é¥Î¥¯¥Þ¥ê¥ó¤ä¥Ù¥ë¥¬¥â¥Ã¥Á¥ó¤Ê¤É
¤Çʸ¸¥¤¢¤µ¤Ã¤Æ¤¤¤Þ¤¹¤¬¡¢¤½¤ì¤È»ØÆ³¤È¤Ï¤Þ¤¿
°ìÀþ°ã¤¦¤â¤Î¤À¤Èǧ¼±¤·¤Æ¤¤¤Þ¤¹¡£
ÉþÌô»ØÆ³¤Ï¥ê¥¹¥¯²óÈò¤òºÇÍ¥Àè¤Ç¤¹¡£
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤ÏIJCYP3A4¤òÁ˳²¤·¤Þ¤¹¡£
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥ÄÃæ¤Î¥Ù¥ë¥¬¥â¥Á¥ó¤¬¸¶°øÊª¼Á¤Ç¤¹¡£
¤¬¡¢1²ó¤Î¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Ç¤ÏÁ˳²¤Ï¤«¤«¤é¤Ê¤¤¤Ï¤º¤Ç¤¹¡£
PubMed¤Ë¤½¤ì¤é¤ÎÏÀʸ¤¬¤¢¤ë¤Ï¤º¡£

³Î¤«¤Ë¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤ÏÎ×¾²Åª¤Ë½ÅÍפʰø»Ò¤«¤â¤·¤ì¤Þ¤»¤ó¤¬¡¢
12ÈÖ¤µ¤ó¤Î½ñ¤­¹þ¤ßÆâÍÆ¤ÎCaÙɹ³Ìô¤Î·ìÃæÇ»ÅÙ¤¬¾å¤¬¤Ã¤¿¤Î¤Ï¡¢
¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Î¤»¤¤¤«¤É¤¦¤«¤Ï¤ï¤«¤ê¤Þ¤»¤ó¡£
¤¿¤Àñ¤ËÎ̤¬Â¿¤«¤Ã¤¿¡¢¶õÊ¢»þ¤Ë°û¤ó¤À²Äǽ¤â¤¢¤ê¤Þ¤¹¡£
ʸÌ̤«¤é¥°¥ì¡¼¥×¥¸¥å¡¼¥¹¤À¤È»×¤¤¤Þ¤¹¤¬¡£¡£¡£

¤Ç¤¹¤Î¤Ç¡¢¤¢¤Þ¤ê¤Ë¤âµ¤¤Ë¤·¤¹¤®¤ë¤Î¤Ï¤É¤¦¤«¤È»×¤¤¤Þ¤¹¡£
¥¿¥à¥í¥ê¥à¥¹¤Î¤è¤¦¤ÊTDM¤¬É¬Íפʼ£ÎŰè¤Î¶¹¤¤Ìôʪ¤ä
½ÅÂç¤ÊÍ­³²È¿±þ¤¬È¯À¸¤¹¤ëÌôʪ¤Ï¿µ½Å¤Ë¤Ê¤ëɬÍפ¬¤¢¤ë¤¬¡¢
°ÂÁ´¤ÊÌô¤Ï¤½¤ì¤Û¤É¹Í¤¨¤Æ¤â¤¤¤¤¤Î¤Ç¤Ï¡©
·ìÃæÇ»ÅÙ¤¬2Çܤ˾夬¤Ã¤Æ¤â¡¢¸ú²Ì¤Ï2ÇܤȤϸ¤ê¤Þ¤»¤ó¡£

¥°¥ì¡¼¥×¥¸¥å¡¼¥¹¤¬¹¥¤­¤Ê´µ¼Ô¤µ¤ó¤Ï°û¤á¤Ê¤¤¤³¤È¤¬QOLÄã²¼
¤È¤Ê¤ê¤Þ¤¹¡Ê¤¤¤¤²á¤®¤«¤â¤·¤ì¤Þ¤»¤ó¤¬¡¦¡¦¡¦¡Ë
¤½¤ÎÊÕ¤ÏÌôºÞ»Õ¤ÎÏӤ諤»½ê¤Ç¤¹¡ª

µÛ¼ý²áÄø¤òÁ˳²¤·¤Þ¤¹¤Î¤Ç¡¢TmaxÉÕ¶á¤Þ¤ÇÈò¤±¤¿¤Û¤¦¤¬¤¤¤¤¤«¤â¡©
¤Ç¤¹¤Î¤Ç¡¢¿©Á°1¡Á2h¡ÁTmaxÉÕ¶á¤ÏÈò¤±¤¿¤Û¤¦¤¬¤¤¤¤¤«¤â¡£

¾Ü¤·¤¯¤ÏÏÀʸ¤Ç¸«¤Ä¤±¤Æ¤¯¤À¤µ¤¤¡Á
>»°Ìᤵ¤ó

»ä¤â¤½¤¦»×¤¤¤Þ¤¹¡£

¤·¤«¤â¡¢¤³¤Î¥°¥ì¡¼¥×¥Õ¥ë¡¼¥Ä¤Þ¤¿¤Ï¥¸¥å¡¼¥¹¤Ç¤ÎÁê¸ßºîÍѤÎÏäÏ̱Êü¤Î°å³Ø·Ï¤ÎÈÖÁȤǤâ´öÅÙ¤â¤È¤ê¤¢¤²¤é¤ì¡¢ºÇ¶á¤ÏÁǿͤµ¤ó¤Ç¤âÃΤäƤޤ¹¡£
´µ¼Ô¤µ¤ó¤ÎÊý¤«¤éʹ¤«¤ì¤ë¤³¤È¤â¤¢¤ê¤Þ¤¹¡£¤½¤ìÄøÍ­Ì¾¤Ë¤Ê¤Ã¤Æ¤Þ¤¹¡£

Ê»ÍÑÃí°Õ¤È¤·¤ÆÅºÉÕʸ½ñ¤Ëµ­ºÜ¤µ¤ì¤Æ¤¤¤ëÌô¤Ë´Ø¤·¤Æ¤Ï¡¢Àݼè¤ò¤ä¤á¤ë¤è¤¦»ØÆ³¤ò¤¹¤ë¤Ù¤­¤À¤È»×¤¤¤Þ¤¹¡£

¥í¥°¥¤¥ó¤¹¤ë¤È¡¢»Ä¤ê3·ï¤Î¥³¥á¥ó¥È¤¬¸«¤ì¤ë¤è

mixi¥æ¡¼¥¶¡¼
¥í¥°¥¤¥ó¤·¤Æ¥³¥á¥ó¥È¤·¤è¤¦¡ª

ÌôºÞ»Õ ¹¹¿·¾ðÊó

ÌôºÞ»Õ¤Î¥á¥ó¥Ð¡¼¤Ï¤³¤ó¤Ê¥³¥ß¥å¥Ë¥Æ¥£¤Ë¤â»²²Ã¤·¤Æ¤¤¤Þ¤¹

À±°õ¤Î¿ô¤Ï¡¢¶¦Ä̤·¤Æ»²²Ã¤·¤Æ¤¤¤ë¥á¥ó¥Ð¡¼¤¬Â¿¤¤¤Û¤ÉÁý¤¨¤Þ¤¹¡£

¿Íµ¤¥³¥ß¥å¥Ë¥Æ¥£¥é¥ó¥­¥ó¥°