Harvard Medical School BostonコミュのMICHAEL SKINNER - CELL BIOLOGY SEMINAR SERIES, ON MONDAY, NOV. 5, FROM 12:15 - 1:30 PM - CANNON RM. AT HMS - BUILDING C

Michael Skinner

Director, Center for Reproductive Biology
School of Molecular Biosciences
Washington State University
Pullman, WA

Epigenetic Transgenerational Actions of Endocrine Disruptors on Reproduction, Disease and Evolution:
The Ghosts in your Genes
Exposure to an environmental endocrine disruptor (such as the fungicide vinclozolin) during embryonic gonadal sex determination appears to alter the male germ line epigenome and subsequently promotes transgenerational adult onset disease. The epigenetic mechanism involves the induction of new imprinted-like genes/DNA sequences in the germ line that appear to transmit disease phenotypes. The disease phenotypes include testis abnormalities, prostate disease, kidney disease, immune abnormalities, and tumor development. This epigenetic transgenerational disease mechanism provides a unique perspective from which to view inheritable adult onset disease states, such as cancer, and ultimately offers new insights into novel diagnostic and therapeutic strategies.

Monday, November 5, 2007

12:15 - 1:30 PM
Building C, Cannon Room Harvard Medical School

Host: Joan Ruderman 617-432-1104