Skeletal Muscleという雑誌が創刊されました。オンラインで無料で全文見ることができるのが嬉しいです。Journal of Cachexia, Sarcopenia and Muscleもそうですが、無料で最新の論文を読むことができるのはありがたいことです。その分、しっかり学習しなければいけない気もしますが…。
Abstract Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in cachectic patients, a major research focus has been to develop strategies stimulating muscle anabolic pathways – in an attempt to fight the catabolic pathways induced during cachexia. Two recent papers have reported the beneficial effects of blocking the myostatin/activin signalling pathway in mouse models of cancer cachexia. We discuss the implications of their findings both with respect to the role that this signalling pathway may play in the aetiology of cachexia and with respect to the prospects for targeting this pathway as a therapeutic strategy in patients with cachexia.
第1号内容 Review Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models Stefano Schiaffino, Cristina Mammucari Skeletal Muscle 2011, 1:4 (24 January 2011)
Research Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation Gabriella Dobrowolny, Michela Aucello, Antonio Musaro Skeletal Muscle 2011, 1:3 (24 January 2011)
Commentary Treating cancer cachexia to treat cancer Se-Jin Lee, David J Glass Skeletal Muscle 2011, 1:2 (24 January 2011)
Editorial Welcome to Skeletal Muscle David J Glass, Kevin P Campbell, Michael A Rudnicki Skeletal Muscle 2011, 1:1 (24 January 2011)