生命科学研究ハイライトコミュの病原体感染とinflammasome

２００７年後半

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.
Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA.
J Exp Med. 2007 Dec 24;204(13):3235-45. Epub 2007 Dec 10.
http://www.ncbi.nlm.nih.gov/pubmed/18070936?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis.
Bergsbaken T, Cookson BT.
PLoS Pathog. 2007 Nov;3(11):e161.
http://www.ncbi.nlm.nih.gov/pubmed/17983266?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES.
Mol Cell. 2007 Oct 26;28(2):214-27.
http://www.ncbi.nlm.nih.gov/pubmed/17964261?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.
Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP.
Cell Host Microbe. 2007 Sep 13;2(3):147-59.
http://www.ncbi.nlm.nih.gov/pubmed/18005730?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nuñez G.
PLoS Pathog. 2007 Aug 10;3(8):e111.
http://www.ncbi.nlm.nih.gov/pubmed/17696608?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

２００７年前半

Type I interferon signaling is required for activation of the inflammasome during Francisella infection.
Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM.
J Exp Med. 2007 May 14;204(5):987-94. Epub 2007 Apr 23.
http://www.ncbi.nlm.nih.gov/pubmed/17452523?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.
Duncan JA, Bergstralh DT, Wang Y, Willingham SB, Ye Z, Zimmermann AG, Ting JP.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8041-6. Epub 2007 May 2.
http://www.ncbi.nlm.nih.gov/pubmed/17483456?ordinalpos=50&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.
Mayor A, Martinon F, De Smedt T, Pétrilli V, Tschopp J.
Nat Immunol. 2007 May;8(5):497-503. Epub 2007 Apr 15.
http://www.ncbi.nlm.nih.gov/pubmed/17435760?ordinalpos=57&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Bruey JM, Bruey-Sedano N, Luciano F, Zhai D, Balpai R, Xu C, Kress CL, Bailly-Maitre B, Li X, Osterman A, Matsuzawa S, Terskikh AV, Faustin B, Reed JC.
Cell. 2007 Apr 6;129(1):45-56.
http://www.ncbi.nlm.nih.gov/pubmed/17418785?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Núñez G.
Immunity. 2007 Apr;26(4):433-43. Epub 2007 Apr 12.
http://www.ncbi.nlm.nih.gov/pubmed/17433728?ordinalpos=58&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.
Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D, Rouiller I, Reed JC.
Mol Cell. 2007 Mar 9;25(5):713-24.
http://www.ncbi.nlm.nih.gov/pubmed/17349957?ordinalpos=67&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

２００６年後半

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival.
Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG.
Cell. 2006 Sep 22;126(6):1135-45.
http://www.ncbi.nlm.nih.gov/pubmed/16990137?ordinalpos=80&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL.
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7. Epub 2006 Jun 19.
http://www.ncbi.nlm.nih.gov/pubmed/16785446?ordinalpos=31&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.
Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A.
Nat Immunol. 2006 Jun;7(6):569-75. Epub 2006 Apr 30.
http://www.ncbi.nlm.nih.gov/pubmed/16648853?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán JE.
J Exp Med. 2006 Jun 12;203(6):1407-12. Epub 2006 May 22.
http://www.ncbi.nlm.nih.gov/pubmed/16717117?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozören N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G.
Nat Immunol. 2006 Jun;7(6):576-82. Epub 2006 Apr 30.
http://www.ncbi.nlm.nih.gov/pubmed/16648852?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

２００６年前半

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.
Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS.
J Exp Med. 2006 Apr 17;203(4):1093-104. Epub 2006 Apr 10.
http://www.ncbi.nlm.nih.gov/pubmed/16606669?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.
Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE.
PLoS Pathog. 2006 Mar;2(3):e18. Epub 2006 Mar 17.
http://www.ncbi.nlm.nih.gov/pubmed/16552444?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Cryopyrin activates the inflammasome in response to toxins and ATP.
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM.
Nature. 2006 Mar 9;440(7081):228-32. Epub 2006 Jan 11.
http://www.ncbi.nlm.nih.gov/pubmed/16407890?ordinalpos=87&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Gout-associated uric acid crystals activate the NALP3 inflammasome.
Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J.
Nature. 2006 Mar 9;440(7081):237-41. Epub 2006 Jan 11.
http://www.ncbi.nlm.nih.gov/pubmed/16407889?ordinalpos=88&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Kanneganti TD, Ozören N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G.
Nature. 2006 Mar 9;440(7081):233-6. Epub 2006 Jan 11.
http://www.ncbi.nlm.nih.gov/pubmed/16407888?ordinalpos=89&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA.
Immunity. 2006 Mar;24(3):317-27.
http://www.ncbi.nlm.nih.gov/pubmed/16546100?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR.
Nat Immunol. 2006 Mar;7(3):318-25. Epub 2006 Jan 29.
http://www.ncbi.nlm.nih.gov/pubmed/16444259?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

２００５年以前

A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection.
Johnston JB, Barrett JW, Nazarian SH, Goodwin M, Ricciuto D, Wang G, McFadden G.
Immunity. 2005 Dec;23(6):587-98. Erratum in: Immunity. 2006 Oct;25(4):687.
http://www.ncbi.nlm.nih.gov/pubmed/16356857?ordinalpos=90&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.
Mariathasan S, Weiss DS, Dixit VM, Monack DM.
J Exp Med. 2005 Oct 17;202(8):1043-9.
http://www.ncbi.nlm.nih.gov/pubmed/16230474?ordinalpos=39&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM.
Nature. 2004 Jul 8;430(6996):213-8. Epub 2004 Jun 9.
http://www.ncbi.nlm.nih.gov/pubmed/15190255?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J.
Immunity. 2004 Mar;20(3):319-25.
http://www.ncbi.nlm.nih.gov/pubmed/15030775?ordinalpos=102&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.
Wright EK, Goodart SA, Growney JD, Hadinoto V, Endrizzi MG, Long EM, Sadigh K, Abney AL, Bernstein-Hanley I, Dietrich WF.
Curr Biol. 2003 Jan 8;13(1):27-36.
http://www.ncbi.nlm.nih.gov/pubmed/12526741?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.
Diez E, Lee SH, Gauthier S, Yaraghi Z, Tremblay M, Vidal S, Gros P.
Nat Genet. 2003 Jan;33(1):55-60. Epub 2002 Dec 16.
http://www.ncbi.nlm.nih.gov/pubmed/12483212?ordinalpos=20&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Martinon F, Burns K, Tschopp J.
Mol Cell. 2002 Aug;10(2):417-26.
http://www.ncbi.nlm.nih.gov/pubmed/12191486?ordinalpos=59&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum