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WHO
Preventing disease with antioxidants. Summary and conclusions. Stockholm, Swedish Council of Technology Assessment in Health Care (SBU), 1997

Among the best known antioxidants are vitamins C and E, beta-carotene, selenium, ubiquinone (Q10) and the flavonoids found in wine, apples, onions and tea.

The scientific literature on antioxidants is extensive and difficult to review and interpret. In 1997, SBU, an independent health technology assessment agency, reviewed 1300 studies in the field. It found no evidence that manufactured antioxidants have any positive effect in preventing disease, except in the case of Vitamin C, where weak evidence showed that large daily doses can relieve, but not prevent, the common cold. The literature had little evidence to indicate that supplementing the diet with antioxidants can prevent cardiovascular diseases, diabetes, neurological disorders, rheumatoid arthritis or cancer. In fact, some dietary supplements have negative effects, particularly at high doses. However, there is some evidence that natural antioxidants (from fruits, vegetables, wine etc.) may prevent several diseases.

Studies have shown that a diet rich in antioxidants, which are primarily provided by fruits and vegetables, may help prevent a variety of serious diseases. However, there is no scientific evidence to show that supplemental antioxidants, beyond those found in a balanced diet that includes fruits and vegetables, will prevent disease. As of 1997, hypotheses presented in this field had yet to be scientifically verified. Controlled scientific studies have shown that high doses of beta-carotene and vitamin E supplements can create serious negative effects in smokers.



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