第36回日本免疫学会総会・学術集会

日　時：　2006年12月11日(月)〜13日(水)

会　場：　大阪国際会議場(グランキューブ大阪)(大阪)

会　長：　平野　俊夫(大阪大学大学院生命機能研究科)

副会長：　審良　静男(大阪大学微生物病研究所)
　　　　　　石原　克彦(大阪大学大学院生命機能研究科)
　　　　　　村上　正晃(大阪大学大学院医学系研究科)

連絡先：　特定非営利活動法人　日本免疫学会

Symposium 1 (Room A) 9:00−11:30 December 11, (Mon)

S1. Innate immunity and inflammation

Chairpersons: Shizuo Akira (Osaka University)
Kensuke Miyake (University of Tokyo)

S1-1 9:00? 9:30 Kensuke Miyake (The University of Tokyo)
Roles for accessory molecules in lipopolysaccharide recognition by Toll-like receptor 4

S1-2 9:30? 10:00 Genhong Cheng (UCLA)
Multiple type I interferon production pathways in response to viral infections

S1-3 10:00? 10:30 Shizuo Akira (Osaka University)
Anti-viral responses via Toll-like receptors and cytoplasmic RNA helicases

S1-4 10:30? 11:00 Takashi Suda (Kanazawa University)
Anti-inflammatory subfamily of Apaf-1 like proteins

S1-5 11:00? 11:30 Gabriel N??ez (University of Michigan)
Role of NLR proteins in innate immunity and disease

Symposium 2 (Room B) 9:00−11:30 December 11, (Mon)

S2. T cell activation, memory and tolerance

Chairpersons: Masaaki Murakami (Osaka University)
Osami Kanagawa (RCAI, RIKEN)

S2-1 9:00? 9:30 Eric Huseby (University of Massachusetts)
How do T cells generate specificity for MHC + peptide complexes?

S2-2 9:30? 9:50 Osami Kanagawa (RCAI, RIKEN)
Age dependent change of peripheral T cell repertoire mediated by interaction between
αβ TCR and self-antigens.

S2-3 9:50? 10:10 Koji Yasutomo (The University of Tokushima)
Regulation of T cell homeostasis by a protein tyrosine phosphatase

S2-4 10:10? 10:40 Stephen P. Schoenberger (La Jolla Institute for Allergy and Immunology)
Programmed tolerance of CD8+ T cells by B cell APC

S2-5 10:40? 11:00 Masaaki Murakami (Osaka University)
Non-hematopoietic cell populations play a role for IL-6-mediated enhancement of CD4
T cell activation.

S2-6 11:00? 11:30 Michael J. Bevan (HHMI and University of Washington)
Generating functional CD8+ T cell memory

Symposium 3 (Room C) 9:00−11:30 December 11, (Mon)

S3. Immunotherapy

Chairpersons: Kazuyuki Yoshizaki (Osaka University)
Nobuyuki Miyasaka (Toyko Medical and Dental University)

S3-1 9:00? 9:30 Charles Garrison Fathman (Stanford University)
Assessing mechanism of response to adoptive cellular gene therapy in nod mice using
MHC sufficient and deficient DCS and gene expression analysis

S3-2 9:30? 10:00 Silvia Gregori (HSR-TIGET)
Cellular therapy with regulatory T cells to restore tolerance

S3-3 10:00? 10:30 Shimon Sakaguchi (Kyoto University)
Control of physiological and pathological immune responses with regulatory T cells

S3-4 10:30? 11:00 Masaru Taniguchi (RCAI, RIKEN)
A phase I/IIa clinical trial on a-GalCer pulsed DC therapy in lung cancer patients

S3-5 11:00? 11:30 Tadamitsu Kishimoto (Osaka University)
IL-6, TH17 and Treg; Why is anti-IL6 receptor effective in autoimmunity

Symposium 4 (Room I) 9:00−11:30 December 11, (Mon)

S4. Cell movement and trafficking

Chairpersons: Toshiyuki Tanaka (Osaka University)
Tatsuo Kinashi (Kansai Medical University)

S4-1 9:00? 9:30 Makoto Iwata (Tokushima Bunri University)
Regulation of lymphocyte trafficking by retinoids

S4-2 9:30? 10:00 Mehrdad Matloubian (UCSF)
Regulation of lymphocyte exit from lymphoid organs

S4-3 10:00? 10:30 Yoshinori Fukui (Kyushu University)
DOCK2 is a Rac activator critical for neutrophil chemotaxis

S4-4 10:30? 11:00 Sho Ishikawa (The University of Tokyo)
Treg trafficking and function in a murine model for SLE

S4-5 11:00? 11:30 Klaus Ley (University of Virginia)
Trafficking of lymphocytes and macrophages to the aorta of normal and atherosclerotic
mice

Symposium 5 (Room A) 9:00−11:30 December 12, (Tue)

S5. Immune recognition, signaling and imaging

Chairpersons: Takashi Saito (RCAI, RIKEN)
Takeshi Tsubata (Tokyo Medical and Dental University)

S5-1 9:00? 9:30 Lawrence E. Samelson (NIH)
Signaling via the T cell antigen receptor

S5-2 9:30? 10:00 Tadashi Yokosuka (RCAI, RIKEN)
TCR microclusters initiate and sustain T cell activation

S5-3 10:00? 10:30 Takeshi Tsubata (Tokyo Medical and Dental University)
Regulated localization of BCR co-receptors CD22 and CD72 on the B cell surface

S5-4 10:30? 11:00 Susan K. Pierce (NIH)
Viewing the initiation of B cell receptor signaling in living cells

S5-5 11:00? 10:30 Michiyuki Matsuda (Kyoto University)
Live cell imaging of the intracellular signal transduction cascades with FRET probes

Symposium 6 (Room B) 9:00−11:30 December 12, (Tue)

S6. Zinc and immunity

Chairpersons: Toshio Hirano (Osaka University and RCAI)
Takehiko Sasazuki (International Medical Center of Japan)

S6-1 9:00? 9:30 Glen K. Andrews (University of Kansas)
Regulation and function of mouse zinc transporter (ZIP) genes

S6-2 9:30? 10:00 Toshio Hirano (Osaka University and RCAI)
Zinc and dendritic cell maturation: Does zinc act as a signaling molecule?

S6-3 10:00? 10:30 Dietmar Kappes (Fox Chase Cancer Center)
Role of the zinc finger transcription factor Th-POK in T cell development and
lymphomagenesis

S6-4 10:30? 11:00 Carola G. Vinuesa (Australian National University)
Roquin, a Ring-1 and CCCH zinc finger protein, is a critical suppressor of autoimmunity

S6-5 11:00? 11:30 Takehiko Sasazuki (International Medical Center of Japan)
A zinc finger transcription factor ZFAT controls autoimmune thyroid diseases through
regulating the expression of immune related genes.

Symposium 7 (Room C) 9:00−11:30 December 12, (Tue)

S7. Allergy

Chairpersons: Hajime Karasuyama (Toyko Medical and Dental University)
Toshinori Nakayama (Chiba University)

S7-1 9:00 ? 9:30 Steven F. Ziegler (Benaroya Research Institute)
TSLP and allergic inflammation

S7-2 9:30 ? 10:00 Hajime Karasuyama (Toyko Medical and Dental University)
Basophils in chronic allergic inflammation

S7-3 10:00 ? 10:30 Toshinori Nakayama (Chiba University)
Memory Th2 cells and allergic responses

S7-4 10:30 ? 11:00 Rick M. Maizels (University of Edinburgh)
Regulatory T cells induced by helminth infection down-modulate airway allergic
inflammation

S7-5 11:00 ? 11:30 Takachika Hiroi (The Tokyo Metropolitan Institute of Medical Science )
Oral tolerance: Peptide immunotherapy for allergic diseases using a rice-based edible
vaccine

Symposium 8 (Room I) 9:00−11:30 December 12, (Tue)

S8. B cell biology

Chairpersons: Akira Shimizu (Kyoto University)
Takeshi Tokuhisa (Chiba University)

S8-1 9:00 ? 9:30 Tasuku Honjo (Kyoto University)
Role of AID and UNG in genomic memory of antigen exposure

S8-2 9:30 ? 10:00 Michel Nussenzweig (HHMI Rockefeller University)
Switching on chromosome translocations

S8-3 10:00 ? 10:30 Frederick Alt (HHMI Harvard Med School)
NHEJ and the double-strand break response in IgH class recombination and
translocations

S8-4 10:30 ? 11:00 Akira Shimizu (Kyoto University)
Control of B cell differentiation and immune response by Id2

S8-5 11:00 ? 11:30 Takeshi Tokuhisa (Chiba University)
A role for Bcl6 in B cells activated with sequential stimulation of IL-4 and IL-21

Symposium 9 (Room A) 9:00−11:30 December 13, (Wed)

S9. Costimulatory molecules and DC

Chairpersons: Hitoshi Kikutani (Osaka University)
Vijay Kuchroo (Harverd Medical School)

S9-1 9:00 ? 9:30 Arlene Sharpe (Harvard Medical School)
Roles of pathways in the B7:CD28 family in regulating T cell activation and tolerance

S9-2 9:30 ? 10:00 Taku Okazaki (Kyoto University)
PD-1 deficiency and autoimmune diseases.

S9-3 10:00 ? 10:30 Vijay Kuchroo (Harvard Medical School)
Costimulatory and inhibitory functions of TIM molecules

S9-4 10:30 ? 11:00 Atsushi Kumanogoh (Osaka University)
Involvement of plexin-A1 in activation and migration of dendritic cells.

S9-5 11:00 ? 11:30 Tsuneyasu Kaisho (RCAI, RIKEN)
Critical roles of IKKα in TLR7/9-stimulated DC

Symposium 10 (Room B) 9:00−12:00 December 13, (Wed)

S10. Late Prof. Yuichi Yamamura memorial symposium

Chairpersons: Tadamitsu Kishimoto (Osaka University)

9:00 ? 9:10 Tadamitsu Kishimoto (Osaka University)
Opening Remark

S10-1 9:10 ? 9:30 Shizuo Akira (Osaka University)
Toll-like receptors as adjuvant receptors which link innate and acquired immunity

S10-2 9:30 ? 9:50 Toshio Hirano (Osaka University and RCAI)
Interaction of immune system with non-immune system induces autoimmune diseases

S10-3 9:50 ? 10:10 Tasuku Honjo (Kyoto University)
Role of AID and UNG in genomic memory of antigen exposure

S10-4 10:10 ? 10:40 William E. Paul (NIH)
Th2 differentiation : Transcription factors and repertoire-determined immunopathology

S10-5 10:40 ? 11:05 Tadatsugu Taniguchi (The University of Tokyo)
Transcriptional regulation in the immune system by the IRF family transcription factors

S10-6 11:05 ? 11:30 Kiyoshi Takatsu (The University of Tokyo)
IL-5: How does it regulate immune response and inflammation?

Symposium 11 (Room C) 9:00−11:30 December 13, (Wed)

S11. Autoimmune diseases

Chairpersons: Tsuneyo Mimori (Kyoto University)
Takayuki Sumida (University of Tsukuba)

S11-1 9:00 ? 9:30 Mark Mamula (Yale University)
The routes of autoantigen presentation in disease

S11-2 9:30 ? 10:00 Jun-ichiro Inoue (The University of Tokyo)
TRAF6 in self-tolerance

S11-3 10:00 ? 10:30 Isao Matsumoto (University of Tsukuba)
Immune responses against ubiquitous glycolytic enzyme leading arthritis- possible link
between human and animal models

S11-4 10:30 ? 11:00 Takao Fujii (Kyoto University)
Generation of regulatory antibodies against T cell receptor by vaccination with CD4+
Th1 clones in lupus-prone mice

S11-5 11:00 ? 11:30 Jennifer H. Anolik (University of Rochester)
Immunobiology of biologic interventions in human autoimmune disease

Symposium 12 (Room G) 9:00−11:30 December 13, (Wed)

S12. Regulation of immune responses by pathogens

Chairpersons: Hisashi Arase (Osaka University)
Shigeo Koyasu (Keio University)

S12-1 9:00 ? 9:30 Hisashi Arase (Osaka University)
Regulation of immunity to pathogens by paired receptors

S12-2 9:30 ? 10:00 Satoshi Koike (Tokyo Metropolitan Institute for Neuroscience )
Role of type I interferon response in tissue tropism and pathogenicity of poliovirus

S12-3 10:00 ? 10:30 Gavin Wilkinson (Cardiff University)
Evasion and stimulation of Natural Killer cells during virus infection

S12-4 10:30 ? 11:00 Shigeo Koyasu (Keio University)
Pathogenic E. coli induces Th1 immunity as an infection strategy by controlling DC
functions

S12-5 11:00 ? 11:30 Soman N. Abraham (Duke University)
Mast cell modulation of immunity to bacterial infections

Symposium 13 (Room I) 9:00−11:30 December 13, (Wed)

S13. Mucosal immunity

Chairpersons: Kiyoshi Takeda (Kyusyu University)
Hiroshi Kiyono (The University of Tokyo)

S13-1 9:00? 9:30 Hiroshi Kiyono (The University of Tokyo)
Lymphoid chemokine family for the initiation and maturation phases of NALT
development and its mediated mucosal immune responses

S13-2 9:30? 10:00 Dennis Kasper (Harvard medical School )
Bacterial polysaccharides provide the Yin and Yang of health and disease during
intestinal colonization

S13-3 10:00? 10:30 Kiyoshi Takeda (Kyushu University)
Nuclear IkB protein-mediated regulation of innate immune responses at the intestinal
mucosa

S13-4 10:30? 11:00 Maria Rescigno (European Institute of Oncology)
Intestinal epithelial cells control dendritic cell function

S13-5 11:00? 11:30 Naoto Ishii (Tohoku University)
Inflammatory bowel disease mediated by OX40 signaling