Gabriel G.Nahas, Nicole Suciu-Foca, Jean-Pierre Armand, Akira Morishima
INHIBITION OF CELLULAR MADIATED IMMUNITY IN MARIHUANA SMOKERS
SCIENCE, VOL.183, FEBURUARY 1974, p419-420
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ABSTRACT. The cellular mediated immunity of 51 young chronic marihuana smokers,
as eval uated by the lymphocyte response in vitro to allogenic cells and to phytohaemaglu-
tinin, was significantly decreased and similar to that of patients in whom impairment of
T (thymus derived) cell immunity is known to occur. This inhibition of blastogenesis might
be related to an impairment of DNA synthesis.
Shelley M.Brown, MD; Barry Stimmel, MD;
Robert N.Taub, MD; Shawl Kochw, PhD;
Richard E. Rodenfield, MD
Thirty-eight heroin addicts, whose immunological
status was studied, had a high incidence of
abnormalities, including hypergammaglobulinemia
(IgM 87% and IgG63%), false-positive test for
syphilis(23%), and positive latex fixation test
(21%). A defect in cellular immunity was demons-
trated by impaired in vitro responsiveness in
lymphocyte culture studies to at least one of
three mitogens when compared to normal controls.
Follow-up studies on ten addicts not taking
heroin but involved in methadone maintenance
programs failed to show a consistent pattern.
This study demonstrates abnormalities in both
the humoral and cellular immune systems in chronic
heroin addicts. there was no apparent correlation
between these abnormalities and the presence of
clinilcal liver diseases. Occult liver diseases,
however, was not excluded by liver biopsy, and
the pathogenesis of these immunologic disturbances
remains speculative.