第2回国際シンポジウム 免疫監視機構 The Second International Symposium on “Immune Surveillance - its cellular and molecular basis, regulation and maintenance” (http://www.immunesurveillance.jp)
8:50- 9:00 Opening Remarks: Takeshi Watanabe
Session I: Spatial and Temporal Organization of Immune Surveillance System
Chairperson: Koji Matsushima
9:00- 9:30 Yosuke Takahama (Univ Tokushima, Japan)
Thymocyte dynamics and central tolerance
9:30-10:00 Mitsuru Matsumoto (Univ. Tokushima, Japan)
Establishment of self-tolerance by thymic stromal factors
10:00-10:30 Ellen A. Robey (Univ. Calif. Berkeley, USA)
Imaging the dynamic behavior of T cells and thymocytes in tissues
10:30-10:45 Coffee Break
Chairperson: Yosuke Takahama
10:45-11:15 Thomas S. Kupper (Harvard Institute of Medicine, USA)
Immunosurveillance of the skin
11:15-11:45 Reina Mebius (VU Univ. Medical Center, Netherland)
Phenotype and function of stromal cells in developing lymph nodes
and inflammatory lesions
11:45-12:15 Shohei Hori (RCAI, RIKEN, Japan)
How Foxp3 controls dominant tolerance: lessons learned from
naturally occurring foxp3 gene mutations
12:15-13:30 Lunch
Session II: Acquisition of Immunological Information, Determination of
Responses, and Maintenance of Memory
Chairperson: Takashi Saito
13:30-14:00 Tatsuo Kinashi (Kansai Med. School, Japan)
Regulation of integrin-dependent lymphocyte adhesion by RAPL
signaling
14:00-14:30 Andrey Shaw (Washington Univ. School of Medicine, USA)
Signaling and the immunological synapse.
14:30-15:00 Takashi Saito (RCAI, RIKEN, Japan)
Spatial regulation of initial and sustained T cell activation
15:00-15:30 Vishva M. Dixit (Genetec Inc., USA)
The inflammasome: A dynamic caspase activating apparatus
15:30-15:45 Coffee Break
Chairperson: Takeshi Tokuhisa
15:45-16:15 Rafi Ahmed (Emory Univ. School of Medicine, USA)
Memory CD8 T cell differentiation during acute versus chronic
viral infection
16:15-16:45 Eric Pamer (Memorial Sloan-Kettering Center, USA)
Viral specific memory T cells
16:45-17:15 Takanori Kanai (Tokyo Med. Dent. Univ., Japan)
Bone marrow latently retaining colitogenic memory CD4+ T cells
may be a pathogenic reservoir for lifelong chronic colitis
17:15-17:45 Toshitada Takemori (RCAI, RIKEN, Japan)
Memory B cell development at the early immune response
18:30- Banquet (Shinagawa Prince Hotel, 27th floor, Nikko no ma)
Session III: Regulation of Immune Response, Malfunction, and Restoration
Chairperson: Toshitada Takemori
9:00-9:30 Jiyang Wang (RCAI, RIKEN, Japan)
Genetic alterations in Ig and non-Ig genes in the germinal center B
cells
9:30-10:00 Tomohiro Kurosaki (RCAI, RIKEN, Japan)
Roles of BCAP and BANK in B cell development and activation
10:00-10:30 Vassiliki A. Boussiotis (Dana-Farber Cancer Inst., USA)
Regulation of p27kip1 expression in T lymphocytes and its role in
cellular immune responses and immune surveillance
10:30-10:45 Coffee Break
Chairperson: Masato Kubo
10:45-11:15 Nagahiro Minato (Kyoto Univ., Japan)
Development of T cell unresponsiveness in systemic leukemia
11:15-11:45 Daniel J. Cua (Schering-Plough BioPharma, USA)
Transcriptional regulation of the Th17 immune responses.
11:45-12:15 Masato Kubo (RCAI, RIKEN, Japan)
Distinct role of Notch signal in allergic and autoimmune responses
12:15-13:30 Lunch
Chairperson: Nagahiro Minato
13:30-14:00 Hajime Karasuyama (Tokyo Med. Dent. Univ., Japan)
Human Tyk2 deficiency as an autosomal recessive form of hyper
IgE syndrome
14:00-14:30 Thomas F. Tedder (Duke Univ. Medical Center, USA)
Restoring malfunctions in humoral immunity and autoimmunity
14:30-15:00 Yoichiro Iwakura (Inst. Med. Sci., Univ. Tokyo, Japan)
The role of c-type lectins in the development of autoimmunity
15:00-15:30 Mark Bonneville (INSERM, France)
Activation modalities of a major human γδ T cell subset and design
of γδ T cell-based immunotherapeutic protocols in cancer patients.
15:30-16:00 Takeshi Watanabe (RCAI, RIKEN, Japan)
Induction of potent secondary immune responses by artificial
lymph nodes in na?ve and immunodeficient mice.